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Top 5 Best Testosterone Boosters for Men Over 40 in 2025: What to Know Before You Buy

Top 5 Best Testosterone Boosters for Men Over 40 in 2025: What to Know Before You Buy

Top 5 Best Testosterone Boosters for Men Over 40 in 2025: What to Know Before You Buy

Natural Testosterone Boosting Supplements are trending among men over 40. But which brands are the best?

Natural Testosterone Boosting Supplements are trending among men over 40. But which brands are the best?

Natural Testosterone Boosting Supplements are trending among men over 40. But which brands are the best?

IMPORTANT:  If you’re looking to boost testosterone naturally, you’re in the right place. I’ve uncovered the top 5 supplements people are switching to improve testosterone — and the common traps that leave most formulas underperforming.

IMPORTANT:  If you’re looking to boost testosterone naturally, you’re in the right place. I’ve uncovered the top 5 supplements people are switching to improve testosterone — and the common traps that leave most formulas underperforming.

IMPORTANT:  If you’re looking to boost testosterone naturally, you’re in the right place. I’ve uncovered the top 5 supplements people are switching to improve testosterone — and the common traps that leave most formulas underperforming.

The Decline of Testosterone:

A Modern Epidemic

The Decline of Testosterone:

A Modern Epidemic

The Decline of Testosterone:

A Modern Epidemic

Testosterone levels in men have dropped 25% compared to our grandfathers. Stress, poor sleep, processed diets, and toxins are destroying natural hormone production. [13]


The impact? Low testosterone drains energy, strength, and focus—making it harder to perform at your best in life and the gym.

Testosterone levels in men have dropped 25% compared to our grandfathers. Stress, poor sleep, processed diets, and toxins are destroying natural hormone production. [13]


The impact? Low testosterone drains energy, strength, and focus—making it harder to perform at your best in life and the gym.

Testosterone levels in men have dropped 25% compared to our grandfathers. Stress, poor sleep, processed diets, and toxins are destroying natural hormone production. [13]


The impact? Low testosterone drains energy, strength, and focus—making it harder to perform at your best in life and the gym.

Testosterone Supports Key Body Systems

Testosterone Supports Key Body Systems

Testosterone Supports Key Body Systems

Muscle & Strength: Supports protein synthesis to build and preserve lean mass [⁶]

Metabolic Health: Helps turn fat into fuel and maintain healthy body composition [⁴][⁵]

Brain & Drive: Backs focus, motivation, and confident intimate drive [⁵]

Bone & Joints: Aids bone density and structural resilience for training [⁶]

Cardio & Endurance: Supports healthy circulation for sustained performance [⁴]

Recovery & Sleep: Encourages restorative sleep and faster post-workout recovery [⁵][⁶]

Muscle & Strength: Supports protein synthesis to build and preserve lean mass [⁶]

Metabolic Health: Helps turn fat into fuel and maintain healthy body composition [⁴][⁵]

Brain & Drive: Backs focus, motivation, and confident intimate drive [⁵]

Bone & Joints: Aids bone density and structural resilience for training [⁶]

Cardio & Endurance: Supports healthy circulation for sustained performance [⁴]

Recovery & Sleep: Encourages restorative sleep and faster post-workout recovery [⁵][⁶]

Muscle & Strength: Supports protein synthesis to build and preserve lean mass [⁶]

Metabolic Health: Helps turn fat into fuel and maintain healthy body composition [⁴][⁵]

Brain & Drive: Backs focus, motivation, and confident intimate drive [⁵]

Bone & Joints: Aids bone density and structural resilience for training [⁶]

Cardio & Endurance: Supports healthy circulation for sustained performance [⁴]

Recovery & Sleep: Encourages restorative sleep and faster post-workout recovery [⁵][⁶]

Why Natural?

Why Natural?

Why Natural?

Natural supplements are the best way to boost testosterone. Here’s why:


Many men turn to synthetic hormones or injections, but these can shut down natural production and trigger side effects like mood swings or water retention. The results don’t last, and stopping often leaves you worse off.[¹][²][³]


Natural testosterone support works with your body. Backed by nutrients and botanicals, it restores balance safely and sustainably — supporting testosterone, energy, recovery, and overall well-being.[⁶]

T Levels Decline Gets Worse With Age

T Levels Decline Gets Worse With Age

T Levels Decline Gets Worse With Age

As men get older, the body naturally produces less testosterone — sometimes starting as early as the late 20s. Even with consistent training, good sleep, and a balanced diet, levels continue to drop year after year. [⁷][⁸][⁹]


The result?


Millions of men experience symptoms tied to low testosterone — like slower muscle gains, reduced energy, and lower drive — often without knowing the cause.


That’s why more experts now recommend natural testosterone support as part of a healthy routine — especially for strength, mood, and overall vitality.

The Good News:

The Good News:

Fortunately, there’s a safe way to fight back. Natural testosterone boosters provide a safe and effective way to support the body’s own production, without the risks of synthetic hormones or injections.


By combining research-backed nutrients and botanicals, these supplements can help restore healthy T levels, improve recovery, and reignite drive and performance (my wife did notice the change). It’s a simple, natural approach to staying strong, sharp, and resilient at any age.

A HIGH-QUALITY TESTOSTERONE BOOSTER MAY HELP

A HIGH-QUALITY TESTOSTERONE BOOSTER MAY HELP

A HIGH-QUALITY TESTOSTERONE BOOSTER MAY HELP

Increase muscle size, strength, and performance [¹⁰]

✔️ Support energy, focus, and motivation [¹¹]

✔️ Promote faster recovery after training [⁶][¹⁰]

✔️ Enhance mood, confidence, and drive [¹⁰]

✔️ Support healthy metabolism and body composition [¹⁰][¹¹]

✔️ Maintain vitality and performance as you age [⁷][⁸][¹¹]

Increase muscle size, strength, and performance [¹⁰]

✔️ Support energy, focus, and motivation [¹¹]

✔️ Promote faster recovery after training [⁶][¹⁰]

✔️ Enhance mood, confidence, and drive [¹⁰]

✔️ Support healthy metabolism and body composition [¹⁰][¹¹]

✔️ Maintain vitality and performance as you age [⁷][⁸][¹¹]

Increase muscle size, strength, and performance [¹⁰]

✔️ Support energy, focus, and motivation [¹¹]

✔️ Promote faster recovery after training [⁶][¹⁰]

✔️ Enhance mood, confidence, and drive [¹⁰]

✔️ Support healthy metabolism and body composition [¹⁰][¹¹]

✔️ Maintain vitality and performance as you age [⁷][⁸][¹¹]

Why Natural Testosterone Support Works So Well

Why Natural Testosterone Support Works So Well

Why Natural Testosterone Support Works So Well

Research shows that testosterone is a key driver of muscle growth, strength, and recovery — helping men build lean mass, perform better in the gym, and bounce back faster after tough workouts. 

It also plays a vital role in mental sharpness and mood, supporting motivation, focus, and the confidence needed to perform at your best. [¹¹]

Healthy testosterone levels are further linked to energy and metabolism, helping the body burn fat more efficiently while maintaining lean muscle.


In addition, testosterone supports overall vitality — from bone health and joint strength to endurance and sexual wellness — making it one of the most important hormones for men’s long-term performance and well-being. [¹⁰][¹¹]

LOW TESTOSTERONE LEVELS MAY LEAD TO

LOW TESTOSTERONE LEVELS MAY LEAD TO

LOW TESTOSTERONE LEVELS MAY LEAD TO

⚠️ Slower muscle growth and strength loss [⁴][⁵]

⚠️ Increased body fat [¹⁰]

⚠️ Reduced energy and constant fatigue [⁶][¹⁰]

⚠️ Lower motivation and drive [⁷][⁸]

⚠️ Declining mood, irritability, or stress [⁸]

⚠️ Slower physical recovery [⁵]

⚠️ Reduced vitality and sexual health [⁶]

WHO’S MOST AT RISK FOR LOW TESTOSTERONE?

WHO’S MOST AT RISK FOR LOW TESTOSTERONE?

WHO’S MOST AT RISK FOR LOW TESTOSTERONE?

🚫 Men over 40 (levels naturally decline with age)

🚫 Those under chronic stress or poor sleep

🚫 Men with excess body fat or metabolic issues

🚫 Anyone with a sedentary lifestyle and low activity levels

What Are the Different Natural Ingredients That Boost T?

What Are the Different Natural Ingredients That Boost T?

What Are the Different Natural Ingredients That Boost T?

When I started researching testosterone boosters, I found a lot of hype. But after digging into the science, a handful of ingredients consistently stood out. If you’re thinking about trying a T-booster, these are the ones you’ll want to see on the label.

T. Ali

— A potent herb traditionally used to restore male performance and hormonal balance.

✔️Shown to naturally boost free testosterone levels
✔️ Enhances strength, energy, and endurance
✔️ Reduces cortisol and supports mood stability
✔️ Supports libido and overall reproductive health

Shilajit

— A mineral-rich compound known for its energy-boosting and revitalizing effects.

✔️ Clinically proven to increase total testosterone
✔️ Enhances mitochondrial energy and physical stamina
✔️ Supports nutrient absorption and recovery
✔️ Promotes healthy aging and cellular function

Ashwagandha

— A powerful adaptogen that supports full-body resilience.

✔️ Helps increase testosterone while lowering stress hormones
✔️ Improves strength, muscle performance, and recovery
✔️ Supports mental clarity, focus, and mood
✔️ May help reduce body fat and support lean mass

Black Maca

— A Peruvian root prized for its role in male vitality and drive.

✔️ Boosts energy, mood, and motivation naturally
✔️ Enhances sexual desire and stamina
✔️ Supports hormone balance and fertility
✔️ Promotes physical performance and endurance

🔥 Hot Tip

🔥 Hot Tip

Look for a testosterone booster that includes Boron — research shows it helps optimize free testosterone and reduces estrogen conversion, making your results more effective.[¹²]


And steer clear of cheap products. Lower-quality boosters often hide behind “proprietary blends” and use dosages too low to make a real difference — meaning you’ll see little to no results.

What You Need to Watch Out For

What You Need to Watch Out For

What You Need to Watch Out For

Not all testosterone boosters are worth your money. After digging through labels and research, here are the biggest red flags I’ve learned to avoid:

🚫 Proprietary Blends
If a label hides behind “blend” instead of exact dosages, it’s usually underdosed and ineffective.


🚫 Weak Dosages
Some products list the right ingredients but in amounts too small to deliver real results.

👉 Pro tip: Choose products with transparent labels, clinical dosages, and third-party testing so you know you’re getting the real deal.

🚫 Fake Reviews
Overly perfect reviews often cover up weak formulas that won’t boost strength or energy.


🚫 Cheap Fillers
Many supplements are padded with junk ingredients that do nothing for testosterone — and may even upset digestion.

Top Test Boosters of 2025: Side-by-Side

Top Test Boosters of 2025: Side-by-Side

Feature

Feature

Formulation Factory

Sladak Naturals

Sladak Naturals

Prime Labs

Prime Labs

Force Factor T

Force Factor T

Prime Male

Prime Male

10 Clinically Studied Ingredients

Transparent Label

Transparent Label

Effective Dosages

Stress relief support

Stress relief support

2-Month Supply Per Bottle

2-Month Supply Per Bottle

3rd-Party Testing

3rd-Party Testing

1. Self Obsessed

1. Self Obsessed

1. Self Obsessed

⭐⭐⭐⭐⭐ Rating 4.8 /5

by Formulation Factory

by Formulation Factory

by Formulation Factory

Rating

Rating

Rating

A+

A+

A+

SHOP NOW

SHOP NOW

SHOP NOW

Pros

Pros

10-in-1 testosterone, energy & vitality formula

10-in-1 testosterone, energy & vitality formula

10-in-1 testosterone, energy & vitality formula

10 clinically studied ingredients at effective dosages

10 clinically studied ingredients at effective dosages

10 clinically studied ingredients at effective dosages

Supports strength, stamina, recovery & mood

Supports strength, stamina, recovery & mood

Supports strength, stamina, recovery & mood

Includes adaptogens like Ashwagandha for cortisol balance

Includes adaptogens like Ashwagandha for cortisol balance

Includes adaptogens like Ashwagandha for cortisol balance

Transparent label — no proprietary blends or hidden fillers

Transparent label — no proprietary blends or hidden fillers

Transparent label — no proprietary blends or hidden fillers

Stimulant-free, clean daily energy

Supports nitric oxide and blood flow

Supports nitric oxide and blood flow

Supports nitric oxide and blood flow

Third-party tested for quality & purity

Third-party tested for quality & purity

Third-party tested for quality & purity

2-month supply per bottle (great value)

2-month supply per bottle (great value)

2-month supply per bottle (great value)

Backed by a 90-day, returnless money-back guarantee

Cons

Cons

Only available online

Only available online

Only available online

Sometimes out of stock due to high demand

Sometimes out of stock due to high demand

Sometimes out of stock due to high demand

A Closer Look

A Closer Look

A Closer Look

Self Obsessed is a high-performance, all-in-one testosterone and vitality booster made for men who want real, research-backed results. It combines 10 clinically studied ingredients — including T. Ali, Shilajit, Ashwagandha, Black Maca, and Zinc — all dosed for impact.


Unlike most products that focus only on testosterone, Self Obsessed supports energy, strength, libido, stress balance, circulation, and recovery, making it an ideal choice for men over 40.


With no proprietary blends, clean labeling, third-party testing, and a generous 2-month supply per bottle, it stands out not only in quality but also in value. Plus, the 90-day returnless guarantee lets you try it completely risk-free.

2. Prime Male

2. Prime Male

2. Prime Male

⭐⭐⭐⭐ Rating 4.2 /5

by Roar Ambition

by Roar Ambition

by Roar Ambition

Rating

Rating

Rating

A

A

A

SHOP NOW

SHOP NOW

SHOP NOW

Pros

Pros

12-ingredient hormone support formula

12-ingredient hormone support formula

12-ingredient hormone support formula

High-potency vitamins & minerals included

High-potency vitamins & minerals included

High-potency vitamins & minerals included

Includes KSM-66 Ashwagandha

Includes KSM-66 Ashwagandha

Includes KSM-66 Ashwagandha

Clean, transparent labeling

Clean, transparent labeling

Clean, transparent labeling

Targets total health & performance

Targets total health & performance

Targets total health & performance

Cons

Cons

Requires 4 pills spaced across the day

Requires 4 pills spaced across the day

Requires 4 pills spaced across the day

Premium price point

Premium price point

Premium price point

Lack clinically-tested doses

Lack clinically-tested doses

Lack clinically-tested doses

A Closer Look

A Closer Look

A Closer Look

Prime Male has built a strong following as a testosterone support supplement, especially for men looking for more of a general health boost than just muscle and performance. The label covers a wide spectrum of vitamins, minerals, and a few proven T-boosters, giving it a “broad coverage” appeal. Users often describe gradual improvements in energy, mood, and libido, though the results tend to come on slower compared to more performance-focused formulas like Self Obsessed.


The biggest trade-offs? Prime Male requires taking multiple capsules daily, which can feel like a chore, and it comes at a higher price point. While its wide-ranging formula makes it a decent option for overall vitality, those who want faster, more noticeable strength and muscle gains may find Self Obsessed a more direct fit.

3. Testosterone Booster

3. Testosterone Booster

3. Testosterone Booster

⭐⭐⭐⭐ Rating 4 /5

by Sladak Naturals

by Sladak Naturals

by Sladak Naturals

Rating

Rating

Rating

C-

C-

C-

SHOP NOW

SHOP NOW

SHOP NOW

Pros

Pros

Herbal formula

Herbal formula

Herbal formula

Vegan, non-GMO, gluten-free

Vegan, non-GMO, gluten-free

Vegan, non-GMO, gluten-free

Good ingredients

Good ingredients

Good ingredients

Cons

Cons

Verified Made in China

Insufficient dosages of important ingredients

Multiple misspellings on the label (sign of a questionable seller/manufacturer)

Multiple misspellings on the label (sign of a questionable seller/manufacturer)

Multiple misspellings on the label (sign of a questionable seller/manufacturer)

Appears to have a large number of fake reviews

Appears to have a large number of fake reviews

Appears to have a large number of fake reviews

A Closer Look

A Closer Look

A Closer Look

Some brands continue to ride on their past reputations, offering subpar supplements that don’t live up to the glowing reviews. Sladak Natural, Prime Labs, and Force Factor—next up in our ranking—are key examples. While these products appear trustworthy due to their high ratings, the reality is often disappointing.


Take this one: despite having over 1,000 reviews and a high Amazon rank, verified sources confirm it’s entirely made and owned by a Chinese company. That alone isn’t a red flag, but it does raise the risk of poor-quality manufacturing and weak quality control, issues commonly associated with offshore production.


That said, it includes some decent ingredients and is very affordable. So if cost is your main concern, it may still be worth considering.

4. Prime Test

4. Prime Test

4. Prime Test

⭐⭐⭐ Rating 3.8 /5

by Prime Labs

by Prime Labs

by Prime Labs

Rating

Rating

Rating

D

D

D

SHOP NOW

SHOP NOW

SHOP NOW

Pros

Pros

Popular, top-ranked testosterone supplement on Amazon.

Popular, top-ranked testosterone supplement on Amazon.

Popular, top-ranked testosterone supplement on Amazon.

Herbal formula

Herbal formula

Herbal formula

Boosts stamina, energy, and workout performance (somewhat)

Boosts stamina, energy, and workout performance (somewhat)

Boosts stamina, energy, and workout performance (somewhat)

Made in the USA, third-party tested

Made in the USA, third-party tested

Made in the USA, third-party tested

Cons

Cons

Proprietary Blend ; usually means the product is cheaply made and consists of mostly cheap ingredients, as there is zero transparency of ingredient doses

Contains orchic extract (controversial ingredient)

Contains orchic extract (controversial ingredient)

Contains orchic extract (controversial ingredient)

Lacks ingredients with proven clinical backing

High quantity of negative reviews

High quantity of negative reviews

High quantity of negative reviews

Many reviews claim dangerous side effects and being hospitalized due to taking the product

Many reviews claim dangerous side effects and being hospitalized due to taking the product

Many reviews claim dangerous side effects and being hospitalized due to taking the product

Some reviews even claim to have opened lawsuits for fraud against this brand

Some reviews even claim to have opened lawsuits for fraud against this brand

Some reviews even claim to have opened lawsuits for fraud against this brand

A Closer Look

A Closer Look

A Closer Look

Being one of the oldest Testosterone Supplements on the market, Prime Labs Prime Test has earned a reputation, accumulating thousands of customer reviews, and has established itself as one of the top-selling test boosters on Amazon, mainly due to how long it’s been around. Many reviews highlight noticeable improvements in energy, stamina, and overall performance. However, this product’s formula is made entirely of a Proprietary Blend—meaning there’s no way to know how much of each ingredient you're actually getting.


Many supplement companies use “proprietary blends” as a loophole in FDA labeling guidelines, which only require them to disclose the total amount of the blend, not the individual components. This can allow manufacturers to load up the formula with cheaper, less effective ingredients while including only trace amounts of the ones that matter. As a general rule, we advise against purchasing supplements that rely on proprietary blends. Combined with this brand’s history—including multiple lawsuits—there’s reasonable concern about whether their formulas truly prioritize the customer’s best interest.

5. Test X180 Gummies

5. Test X180 Gummies

5. Test X180 Gummies

⭐⭐⭐ Rating 3.2 /5

by Force Factor

by Force Factor

by Force Factor

Rating

Rating

Rating

F

F

F

SHOP NOW

SHOP NOW

SHOP NOW

Pros

Pros

Convenient gummy format, easy to take

Convenient gummy format, easy to take

Convenient gummy format, easy to take

No artificial colors, sweeteners, or preservatives

No artificial colors, sweeteners, or preservatives

No artificial colors, sweeteners, or preservatives

Cons

Cons

Extremely low dosages

Extremely low dosages

Extremely low dosages

Gummies format may contain less potency per serving compared to capsules

Gummies format may contain less potency per serving compared to capsules

Gummies format may contain less potency per serving compared to capsules

Less comprehensive in vitamin/mineral support

A Closer Look

A Closer Look

A Closer Look

We won’t “sugar coat” this one, the Force Factor Test X180 Gummy is nothing but a glorified sweet. If you check their Supplement Facts and know anything about supplement labeling, the first thing you’ll notice (that not enough consumers are aware of):  their active ingredients that are supposed to boost testosterone are in “mcg” (micrograms), NOT “mg” (milligrams). For those that aren’t familiar with supplement labeling, that means this “supplement”  is 1000 times less potent than almost any testosterone capsule supplement on the market. 


For more context, 1 mg = 1000 mcg. Your average testosterone capsule sup will have 400-600+ mg (milligrams) of active ingredients per serving. Change that to mcg (micrograms), and you might as well be eating candy gummy bears.

2025’s Top-Rated Natural Testosterone Support for Men Over 40

2025’s Top-Rated Natural Testosterone Support for Men Over 40

2025’s Top-Rated Natural Testosterone Support for Men Over 40

Self Obsessed

Self Obsessed

Self Obsessed

by Formulation Factory

by Formulation Factory

by Formulation Factory

10-in-1 testosterone, energy & vitality formula

10-in-1 testosterone, energy & vitality formula

10-in-1 testosterone, energy & vitality formula

Supports strength, stamina, recovery & mood

Supports strength, stamina, recovery & mood

Supports strength, stamina, recovery & mood

Includes adaptogens like Ashwagandha for cortisol balance

Includes adaptogens like Ashwagandha for cortisol balance

Includes adaptogens like Ashwagandha for cortisol balance

Transparent label — no proprietary blends or hidden fillers

Transparent label — no proprietary blends or hidden fillers

Transparent label — no proprietary blends or hidden fillers

Stimulant-free, clean daily energy

Stimulant-free, clean daily energy

Stimulant-free, clean daily energy

SHOP NOW

SHOP NOW

SHOP NOW

DISCLAIMER:  The scientific research provided is for informational purposes only. Individual results may vary. This page shares this information as a resource and does not endorse it. This content should not be considered a recommendation or endorsement of any specific products.

DISCLAIMER:  The scientific research provided is for informational purposes only. Individual results may vary. This page shares this information as a resource and does not endorse it. This content should not be considered a recommendation or endorsement of any specific products.

DISCLAIMER:  The scientific research provided is for informational purposes only. Individual results may vary. This page shares this information as a resource and does not endorse it. This content should not be considered a recommendation or endorsement of any specific products.

Scientific Research

1. Montori, V. M., et al. Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 95(6), 2560–2575 (2010). This meta-analysis found that testosterone treatment in men was associated with significant increases in hemoglobin (+0.80 g/dL) and hematocrit (+3.18%), as well as a decrease in HDL (“good”) cholesterol.


  1. Montori, V. M., et al. Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 95(6), 2560–2575 (2010). This meta-analysis found that testosterone treatment in men was associated with significant increases in hemoglobin (+0.80 g/dL) and hematocrit (+3.18%), as well as a decrease in HDL (“good”) cholesterol.


  2. Management of Adverse Effects in Testosterone Replacement Therapy. Brazilian Journal of Urology (SciELO), 51(3), May–June 2025. This narrative review outlines various adverse effects of testosterone replacement therapy — including gynecomastia, cardiovascular and hematologic risks, prostate health concerns, and potential liver dysfunction.

  3. The Mayo Clinic. Testosterone Therapy: Potential benefits and risks as you age. (2023). This overview highlights several risks of testosterone therapy, such as the potential to exacerbate sleep apnea, cause acne or other skin issues, and uncertain improvements in vitality or energy.

  4. Zhao, W., Li, H., Zhang, Y., Chen, R., & Liu, X. (2025). Association of serum testosterone levels with appendicular lean mass in men: Evidence from NHANES 2011–2016. Frontiers in Physiology, 16, 1512268.

  5. Strasser, B., Arvandi, M., & Siebert, U. (2024). Effects of testosterone and exercise on muscle performance in older men: A systematic review and meta-analysis. Sports Medicine – Open, 10, 703.

  6. Pokrywka, A., Obmiński, Z., & Malczewska-Lenczowska, J. (2023). Tribulus terrestris supplementation improves body composition and hormone response in men during training: A six-week randomized controlled trial. International Journal of Impotence Research, 35, 763–770.

  7. Zirkin, B. R., & Tenover, J. L. (2012). Aging and declining testosterone: Past, present, and hopes for the future. Journal of Andrology, 33(6), 1111–1118.

  8. Golan, R., Scovell, J. M., & Ramasamy, R. (2015). Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. The Aging Male, 18(3), 201–205.

  9. Nardozza Júnior, A., Szelbracikowski, S. S., Nardi, A. C., & de Almeida, J. C. (2011, October). Age-related testosterone decline in a Brazilian cohort of healthy military men. International Braz J Urol, 37(5), 591–597.

  10. Rojas-Zambrano, J. G., Rojas-Zambrano, A., & Rojas-Zambrano, A. F. (2025). Impact of testosterone on male health: A systematic review. Cureus, 17(4), e82917.

  11. Hildreth, K. L., Barry, D. W., Moreau, K. L., Vande Griend, J., Meacham, R. B., Nakamura, T., Wolfe, P., Kohrt, W. M., Ruscin, J. M., Kittelson, J., Cress, M. E., Ballard, R., & Schwartz, R. S. (2013). Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. Journal of Clinical Endocrinology & Metabolism, 98(5), 1891–1900.

  12. Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M., & Daneshpour, M.-S. (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of Trace Elements in Medicine and Biology, 25(1), 54–58.


  13. Lokeshwar, S. D., Patel, P., Fantus, R. J., Halpern, J., Chang, C., Kargi, A. Y., & Ramasamy, R. (2020). Decline in serum testosterone levels among adolescent and young adult men in the USA. European Urology Focus, 6(3), 432–440.

Scientific Research

1. Montori, V. M., et al. Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 95(6), 2560–2575 (2010). This meta-analysis found that testosterone treatment in men was associated with significant increases in hemoglobin (+0.80 g/dL) and hematocrit (+3.18%), as well as a decrease in HDL (“good”) cholesterol.


  1. Montori, V. M., et al. Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 95(6), 2560–2575 (2010). This meta-analysis found that testosterone treatment in men was associated with significant increases in hemoglobin (+0.80 g/dL) and hematocrit (+3.18%), as well as a decrease in HDL (“good”) cholesterol.


  2. Management of Adverse Effects in Testosterone Replacement Therapy. Brazilian Journal of Urology (SciELO), 51(3), May–June 2025. This narrative review outlines various adverse effects of testosterone replacement therapy — including gynecomastia, cardiovascular and hematologic risks, prostate health concerns, and potential liver dysfunction.

  3. The Mayo Clinic. Testosterone Therapy: Potential benefits and risks as you age. (2023). This overview highlights several risks of testosterone therapy, such as the potential to exacerbate sleep apnea, cause acne or other skin issues, and uncertain improvements in vitality or energy.

  4. Zhao, W., Li, H., Zhang, Y., Chen, R., & Liu, X. (2025). Association of serum testosterone levels with appendicular lean mass in men: Evidence from NHANES 2011–2016. Frontiers in Physiology, 16, 1512268.

  5. Strasser, B., Arvandi, M., & Siebert, U. (2024). Effects of testosterone and exercise on muscle performance in older men: A systematic review and meta-analysis. Sports Medicine – Open, 10, 703.

  6. Pokrywka, A., Obmiński, Z., & Malczewska-Lenczowska, J. (2023). Tribulus terrestris supplementation improves body composition and hormone response in men during training: A six-week randomized controlled trial. International Journal of Impotence Research, 35, 763–770.

  7. Zirkin, B. R., & Tenover, J. L. (2012). Aging and declining testosterone: Past, present, and hopes for the future. Journal of Andrology, 33(6), 1111–1118.

  8. Golan, R., Scovell, J. M., & Ramasamy, R. (2015). Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. The Aging Male, 18(3), 201–205.

  9. Nardozza Júnior, A., Szelbracikowski, S. S., Nardi, A. C., & de Almeida, J. C. (2011, October). Age-related testosterone decline in a Brazilian cohort of healthy military men. International Braz J Urol, 37(5), 591–597.

  10. Rojas-Zambrano, J. G., Rojas-Zambrano, A., & Rojas-Zambrano, A. F. (2025). Impact of testosterone on male health: A systematic review. Cureus, 17(4), e82917.

  11. Hildreth, K. L., Barry, D. W., Moreau, K. L., Vande Griend, J., Meacham, R. B., Nakamura, T., Wolfe, P., Kohrt, W. M., Ruscin, J. M., Kittelson, J., Cress, M. E., Ballard, R., & Schwartz, R. S. (2013). Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. Journal of Clinical Endocrinology & Metabolism, 98(5), 1891–1900.

  12. Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M., & Daneshpour, M.-S. (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of Trace Elements in Medicine and Biology, 25(1), 54–58.


  13. Lokeshwar, S. D., Patel, P., Fantus, R. J., Halpern, J., Chang, C., Kargi, A. Y., & Ramasamy, R. (2020). Decline in serum testosterone levels among adolescent and young adult men in the USA. European Urology Focus, 6(3), 432–440.

Scientific Research

  1. Montori, V. M., et al. Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 95(6), 2560–2575 (2010). This meta-analysis found that testosterone treatment in men was associated with significant increases in hemoglobin (+0.80 g/dL) and hematocrit (+3.18%), as well as a decrease in HDL (“good”) cholesterol.


  2. Management of Adverse Effects in Testosterone Replacement Therapy. Brazilian Journal of Urology (SciELO), 51(3), May–June 2025. This narrative review outlines various adverse effects of testosterone replacement therapy — including gynecomastia, cardiovascular and hematologic risks, prostate health concerns, and potential liver dysfunction.


  3. The Mayo Clinic. Testosterone Therapy: Potential benefits and risks as you age. (2023). This overview highlights several risks of testosterone therapy, such as the potential to exacerbate sleep apnea, cause acne or other skin issues, and uncertain improvements in vitality or energy.


  4. Zhao, W., Li, H., Zhang, Y., Chen, R., & Liu, X. (2025). Association of serum testosterone levels with appendicular lean mass in men: Evidence from NHANES 2011–2016. Frontiers in Physiology, 16, 1512268.

  5. Strasser, B., Arvandi, M., & Siebert, U. (2024). Effects of testosterone and exercise on muscle performance in older men: A systematic review and meta-analysis. Sports Medicine – Open, 10, 703.

  6. Pokrywka, A., Obmiński, Z., & Malczewska-Lenczowska, J. (2023). Tribulus terrestris supplementation improves body composition and hormone response in men during training: A six-week randomized controlled trial. International Journal of Impotence Research, 35, 763–770.

  7. Zirkin, B. R., & Tenover, J. L. (2012). Aging and declining testosterone: Past, present, and hopes for the future. Journal of Andrology, 33(6), 1111–1118.

  8. Golan, R., Scovell, J. M., & Ramasamy, R. (2015). Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. The Aging Male, 18(3), 201–205.

  9. Nardozza Júnior, A., Szelbracikowski, S. S., Nardi, A. C., & de Almeida, J. C. (2011, October). Age-related testosterone decline in a Brazilian cohort of healthy military men. International Braz J Urol, 37(5), 591–597.

  10. Rojas-Zambrano, J. G., Rojas-Zambrano, A., & Rojas-Zambrano, A. F. (2025). Impact of testosterone on male health: A systematic review. Cureus, 17(4), e82917.

  11. Hildreth, K. L., Barry, D. W., Moreau, K. L., Vande Griend, J., Meacham, R. B., Nakamura, T., Wolfe, P., Kohrt, W. M., Ruscin, J. M., Kittelson, J., Cress, M. E., Ballard, R., & Schwartz, R. S. (2013). Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. Journal of Clinical Endocrinology & Metabolism, 98(5), 1891–1900.

  12. Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M., & Daneshpour, M.-S. (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of Trace Elements in Medicine and Biology, 25(1), 54–58.


  13. Lokeshwar, S. D., Patel, P., Fantus, R. J., Halpern, J., Chang, C., Kargi, A. Y., & Ramasamy, R. (2020). Decline in serum testosterone levels among adolescent and young adult men in the USA. European Urology Focus, 6(3), 432–440.